Alpha-halocarboxylic acids and derivatives
Sigma Organic Chemistry Ethyl bromoacetate | 500G | 105-36-2 | MFCD00000191
CAS #: 105-36-2
MDL #: MFCD00000191
Purity: >98 %
UNSPSC Code: 12352100
Molecular Weight: 167
Sigma Organic Chemistry Methyl chloroacetate | 1KG | 96-34-4 | MFCD00000931
CAS #: 96-34-4
MDL #: MFCD00000931
Purity: >99 %
UNSPSC Code: 12352100
Molecular Weight: 108.52
Sigma Organic Chemistry Chloroacetic anhydride | 25G | 541-88-8 | MFCD00000929
CAS #: 541-88-8
MDL #: MFCD00000929
Purity: >95 %
UNSPSC Code: 12352100
Molecular Weight: 170.98
AdipoGen Naphthol AS-D chloroacetate
Chemical. CAS 35245-26-2. Formula C20H16ClNO3. MW BD9837. Naphthol AS-D chloroacetate NASDCA is a fluorigenic substrate for granulocyte specific esterases e.g. Proteinase 3 PR3 and Cathepsin G. It can be hydrolyzed into Naphthol AS-D by esterases to mix with diazonium salt and form insoluble red-brown precipitate in the cytoplasm that can be visualized under a microscope. This enzyme is usually considered specific for cells of granulocytic lineage. NASDCA can be used for the visualisation of cells in formalin-fixed or paraffin-embedded tissue in a substrate solution for naphthol-AS-D-chloroacetate-esterase CIAE staining. Proteinase 3 P3R is a serine protease that is found in neutrophils and a subpopulation of monocytes. It is the most specific enzyme for NASDCA hydrolysis, and it is used in a variety of diagnostic tests to detect granulocytes. Cathepsin G is another serine protease that is found in neutrophils.
AdipoGen Saquayamycin B1
Chemical. CAS 99260-68-1. Formula C31H32O12. MW 596.6. Isolated from Streptomyces nodosus. Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukaemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase NOS shown for Saquayamycin A1.
AdipoGen Bafilomycin B1
Chemical. CAS 88899-56-3. Formula C44H65NO13. MW 815.9. Isolated from Streptomyces hygroscopicus. Macrolide antibiotic. Specific vacuolar-type H-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Antitrypanosomal and antileishmanial compound. Phytotoxic. Influences the cell wall biosynthesis of Asp. niger.
Cayman Chemical IRL 1620 trifluoroacetate sa
An antagonist of GHS-R1a (Ki 0 017 UM) selective for GHS-R1a over the motilin receptor (Ki 6 UM) and a panel of 30 receptors and enzymes (Kis 10 UM) prevents ghrelin-induced decreases in insulin secretion in glucose-stimulated isolated rat pancreatic islets at 1 UM increases plasma insulin levels and decreases blood glucose levels in rats in an intraperitoneal glucose tolerance test at 0 3 or 10 mg/kg respectively inhibits cocaine-induced hyperlocomotion in mice at 10 and 20 mg/kg
AdipoGen Saquayamycin B1
Chemical. CAS 99260-68-1. Formula C31H32O12. MW 596.6. Isolated from Streptomyces nodosus. Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukaemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase NOS shown for Saquayamycin A1.
AdipoGen GE23077 A1 B1
Chemical. CAS 752989-46-1, 752989-45-0752989-44-9. Formula C31H51N9O16, C31H49N9O16. MW 805.8803.8. Isolated from Actinomadura sp. Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase RNAP. Inhibits Gram-positive Bacillus subtilis and Gram-negative Escherichia coli RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic wheat germ RNAP II IC50 values >100µM. Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of memmbrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase RNAP active-center i and i1 nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation.
